Will I need regular blood testing on the anticoagulant you are putting me on?

It is not unreasonable to check the complete blood count (CBC) and comprehensive metabolic panel (CMP) 1 – 2 times a year. If you are on coumadin you will need frequent blood testing about every 3 weeks. If you are on a DOAC like Apixaban or Rivaroxaban you will need blood testing less frequently (maybe every 6 months to make sure your kidney function is stable).


Will my anticoagulants interact with other medications?

Yes, anticoagulants can have issues with other medications. Check with your doctor before getting prescribed anything like NSAID. Xarelto and Eliquis can react with certain seizure medicines, HIV medicines, anti-fungal medications, and TB medicines. There are very few other interactions. However, you should not take Xarelto with Paxlovid since it has an HIV medicine Ritonavir.  With Apixaban you should use half dose. warfarin (Coumadin) has many interactions, which is a good reason to use DOACs if you can for blood clots involving the legs and lungs.


What are reversal agents for anticoagulants?

There are some reversal agents for anticoagulants: Idarucizumab (reversal for dabigatran) & and Andexanet (reversal for apixaban (Eliquis), rivaroxaban (Xarelto), and (off-label) enoxaparin (Lovenox, and generics) in patients with active major bleeding. These are rarely used except for major life-threatening bleeds involving the brain or GI tract.


How do you know if someone will have to be on anticoagulants for life?

Usually, you would decide this based on if the blood clot was provoked or unprovoked and whether on-going risk factors are present such as obesity (body mass index >30) or being above the age of 55. Permanent risk factors or unprovoked blood clots are most likely to be treated long term because they have the highest rates of recurrence.


How do I know what anticoagulation medication to choose?

Talk to your healthcare team about which medication is right for you. Usually a direct anticoagulant (DOAC) such as Eliquis (apixaban) or Xarelto (rivaroxaban) is prescribed over warfarin (coumadin) as they are not affected by your diet nor most medications like warfarin. They also do not require periodic blood draw monitoring, but one exception is APAS. Eliquis is typically prescribed if there is a perceived higher bleeding risk i.e., menstruating female or if the patient has renal failure while Xarelto is preferable due to daily dosing instead of twice a day with Eliquis. Endoxaban and Dabigatran (Pradaxa) are other DOACs that do not require monitoring. Regardless of what anticoagulation medication is chosen, the treatment goals should include:
  • Stop an existing clot from growing
  • Preventing the formation of a new clot in other vein segments that could break off and travel to the lungs and become a PE
  • Avoiding or minimizing any long-term complications


What are the potential side effects of anticoagulants?

There are three main anticoagulants: rivaroxaban (Xarelto), apixaban (Eliquis), dabigatran (Pradaxa which is less common). Potential side effects include:
  • An unfamiliar headache
    • While you will notice bleeding from your GI tract, your nose, and your skin; you may not realize that an unfamiliar headache can be a sign of bleeding in the brain so if you get an unfamiliar or more severe than usual headache you should contact your doctor
  • Blood in your urine or stools
  • In women, heavy bleeding during a period or excessive vaginal bleeding during the 6-week post-partum period
  • Severe bruising
  • Prolonged nosebleeds (lasting longer than 10 minutes)
  • Coughing up blood
  • If you have hemorrhoids, you might bleed a little more
  • Learn more about Warfarin or Heparin.


How do anticoagulants work?

These medications do not actually “thin” the blood, they do slow the body’s ability to form new clots, keep existing clots from getting bigger, and they prevent clots from travelling or embolizing.


Who should know that I am on anticoagulants?

Make sure to tell your entire medical team, including your primary care physician and other providers like your dentist. Every dentist handles anticoagulants differently.


How can I decide which anticoagulant is best for me?

This is a decision you make with your doctor, based on your health history and what works best in terms of your ability to take your medicine, your ability to get to a lab for blood tests, and what the medication costs. The main safety step is to take the dose at the right time your doctor tells you and do not skip or double doses.


What is the difference between anticoagulants and blood thinners?

Nothing. These terms can be used interchangeably.


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