How does fondaparinux work?

Fondaparinux (Arixtra®) differs from standard heparin and LMWH in several ways. In particular, it does not come from animal sources. Instead, this drug is a synthetic version of the active site of the heparin molecule and is an even smaller molecule than LMWH. Heparin blocks both thrombin and factor Xa, whereas LMWH has relatively more activity against factor Xa and relatively less activity against thrombin. By contrast, fondaparinux acts exclusively against factor Xa—it does not affect thrombin. Fondaparinux does not require monitoring.

Current News

Expecting or recently had a baby? Don’t let a blood clot spoil your joy.

Today, the National Blood Clot Alliance, in collaboration with the Centers for Disease Control …

Back to Campus: Birth Control & Blood Clots

Millions of students will be stepping on campuses across the United States in the upcoming …