How does fondaparinux work?

Fondaparinux (Arixtra®) differs from standard heparin and LMWH in several ways. In particular, it does not come from animal sources. Instead, this drug is a synthetic version of the active site of the heparin molecule and is an even smaller molecule than LMWH. Heparin blocks both thrombin and factor Xa, whereas LMWH has relatively more activity against factor Xa and relatively less activity against thrombin. By contrast, fondaparinux acts exclusively against factor Xa—it does not affect thrombin. Fondaparinux does not require monitoring.

Current News

The National Blood Clot Alliance Launches New Council for Emerging Researchers in Thrombosis (CERT)

FOR IMMEDIATE RELEASE: 07/28/2022   The National Blood Clot Alliance (NBCA), the nation’s leading nonprofit patient advocacy organization dedicated to…

The FUVID Study

The FUVID Study (Functional Characterization of Chronic Thromboembolic Venous Disease in Children) is currently open for enrollment to qualified participants.…