Aspirin and Blood Clots

What is the Role of Aspirin in Preventing Recurrent Venous Thromboembolism? For several decades, aspirin has been the mainstay of antithrombotic therapy to prevent recurrent arterial thrombotic events. Aspirin is also effective in the primary prevention of myocardial infarction, particularly in men. For the prevention of deep venous thrombosis and pulmonary embolism, anticoagulants are the…

Home Monitoring for Warfarin Therapy

The Status of INR Home Monitoring for Warfarin Therapy Warfarin has been the principal oral anticoagulant (blood thinner) in use in the United States for a variety of blood clotting (thrombotic) diseases since the 1950s. Warfarin therapy, however, has many drawbacks, principally among them, the complexity and labor intensiveness of managing therapy and the high risk of adverse events often…

PREGNANCY, BLOOD CLOTS AND ANTICOAGULATION

Pregnancy requires special consideration with respect to the prevention and treatment of blood clots. Pregnancy does not cause blood clots, but increases the chance that a blood clot will develop by four- to five-fold. Pregnancy’s tendency to form clots is an evolutionary response to protect women against the bleeding challenges of miscarriage and childbirth. In…

Why Anticoagulants May Do More Than “Stop-the-Clot” in Patients with Cancer

We have all been taught that blood clotting proteins and blood platelets do one thing– clot our blood to protect us from bleeding. Deficient production or production of defective clotting proteins or platelets results in bleeding disorders. Increased production, increased activity or reduced clearance (elimination) of activated clotting proteins or platelets can result in blood clots or thrombosis….

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INR Self Testing

INR Self Testing Stephan Moll, MD; University of North Carolina, Chapel Hill, NC Jack Ansell, MD; Boston University Medical Center; Boston, MA Warfarin and the INR If you are on warfarin (Coumadin®, Jantoven®), you regularly need a blood test called prothrombin time, protime or PT, with the result of the test called INR – International…